Functional Imaging of Proteolysis: Stromal and Inflammatory Cells Increase Tumor Proteolysis

Direct imaging of APP proteolysis in living cells

Alzheimer's disease is a multifactorial disorder caused by the interaction of genetic, epigenetic and environmental factors. The formation of cytotoxic oligomers consisting of Aβ peptide is widely accepted as being one of the main key events triggering the development of Alzheimer's disease. Aβ peptide production results from the specific proteolytic processing of the amyloid precursor protein ...

Proteolysis of CCN1 by plasmin: functional implications.

Plasmin is shown to play a crucial role in many pathophysiologic processes primarily through its ability to degrade extracellular matrix (ECM) and/or mobilizing growth factors that are sequestered in the ECM. Cysteine-rich 61 (CCN1) is a matricellular protein of which expression is up-regulated in cancer and various vascular diseases. The present study was undertaken to investigate whether plas...

Pulmonary Emphysema and Proteolysis

The book's only general defect is the uneven quality, which is probably inevitable when editors must wring finished manuscripts from a large number of contributors who have a variety of other pressing professional concerns. Some authors have simply described the current state of their own research, without troubling to add the two or three literature review paragraphs which establish the histor...

Intramembrane Proteolysis of Signal

Acid-mediated tumor proteolysis: contribution of cysteine cathepsins.

One of the noncellular microenvironmental factors that contribute to malignancy of solid tumors is acidic peritumoral pH. We have previously demonstrated that extracellular acidosis leads to localization of the cysteine pro-tease cathepsin B on the tumor cell membrane and its secretion. The objective of the present study was to determine if an acidic extracellular pH such as that observed in vi...